North is a town in Orangeburg County, South Carolina, United States. The population was 754 at the 2010 census. North, South Carolina, has been noted for its unusual place name.In 1891 the SouthBound Railway Company came through the area with the assistance of John F. North. In 1892 John North, along with George W. Pou and Sampson A. Livingston, donated 100 acres for the railway depot and townsite. A US Post Office was established. The next year John North, a Confederate vetern and businessman, was elected the first mayor of his namesake town of North, South Carolina.